Rhythmic auditory stimulation modulates gait variability in Parkinson's disease
Identifieur interne : 000731 ( Main/Corpus ); précédent : 000730; suivant : 000732Rhythmic auditory stimulation modulates gait variability in Parkinson's disease
Auteurs : Jeffrey M. Hausdorff ; Justine Lowenthal ; Talia Herman ; Leor Gruendlinger ; Chava Peretz ; Nir GiladiSource :
- European Journal of Neuroscience [ 0953-816X ] ; 2007-10.
English descriptors
Abstract
Patients with Parkinson's disease (PD) walk with a shortened stride length and high stride‐to‐stride variability, a measure associated with fall risk. Rhythmic auditory stimulation (RAS) improves stride length but the effects on stride‐to‐stride variability, a marker of fall risk, are unknown. The effects of RAS on stride time variability, swing time variability and spatial‐temporal measures were examined during 100‐m walks with the RAS beat set to 100 and 110% of each subject's usual cadence in 29 patients with idiopathic PD and 26 healthy age‐matched controls. Carryover effects were also evaluated. During usual walking, variability was significantly higher (worse) in the patients with PD compared with the controls (P < 0.01). For the patients with PD, RAS at 100% improved gait speed, stride length and swing time (P < 0.02) but did not significantly affect variability. With RAS at 110%, reductions in variability were also observed (P < 0.03) and these effects persisted 2 and 15 min later. In the control subjects, the positive effects of RAS were not observed. For example, RAS increased stride time variability at 100 and 110%. These results demonstrate that RAS enables more automatic movement and reduces stride‐to‐stride variability in patients with PD. Further, these improvements are not simply a by‐product of changes in speed or stride length. After walking with RAS, there also appears to be a carryover effect that supports the possibility of motor plasticity in the networks controlling rhythmicity in PD and the potential for using RAS as an intervention to improve mobility and reduce fall risk.
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DOI: 10.1111/j.1460-9568.2007.05810.x
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Hausdorff</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Division on Aging, Harvard Medical School, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Lowenthal, Justine" sort="Lowenthal, Justine" uniqKey="Lowenthal J" first="Justine" last="Lowenthal">Justine Lowenthal</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author><author><name sortKey="Herman, Talia" sort="Herman, Talia" uniqKey="Herman T" first="Talia" last="Herman">Talia Herman</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation></author><author><name sortKey="Gruendlinger, Leor" sort="Gruendlinger, Leor" uniqKey="Gruendlinger L" first="Leor" last="Gruendlinger">Leor Gruendlinger</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation></author><author><name sortKey="Peretz, Chava" sort="Peretz, Chava" uniqKey="Peretz C" first="Chava" last="Peretz">Chava Peretz</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D101ECC4713784EC04554F09B1237CA4DC874DF4</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1111/j.1460-9568.2007.05810.x</idno><idno type="url">https://api.istex.fr/document/D101ECC4713784EC04554F09B1237CA4DC874DF4/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000731</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Rhythmic auditory stimulation modulates gait variability in Parkinson's disease</title><author><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Division on Aging, Harvard Medical School, Boston, MA, USA</mods:affiliation></affiliation></author><author><name sortKey="Lowenthal, Justine" sort="Lowenthal, Justine" uniqKey="Lowenthal J" first="Justine" last="Lowenthal">Justine Lowenthal</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author><author><name sortKey="Herman, Talia" sort="Herman, Talia" uniqKey="Herman T" first="Talia" last="Herman">Talia Herman</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation></author><author><name sortKey="Gruendlinger, Leor" sort="Gruendlinger, Leor" uniqKey="Gruendlinger L" first="Leor" last="Gruendlinger">Leor Gruendlinger</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation></author><author><name sortKey="Peretz, Chava" sort="Peretz, Chava" uniqKey="Peretz C" first="Chava" last="Peretz">Chava Peretz</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><mods:affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-10">2007-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="2369">2369</biblScope><biblScope unit="page" to="2375">2375</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">D101ECC4713784EC04554F09B1237CA4DC874DF4</idno><idno type="DOI">10.1111/j.1460-9568.2007.05810.x</idno><idno type="ArticleID">EJN5810</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>gait variability</term><term>plasticity</term><term>rhythmic auditory stimulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) walk with a shortened stride length and high stride‐to‐stride variability, a measure associated with fall risk. Rhythmic auditory stimulation (RAS) improves stride length but the effects on stride‐to‐stride variability, a marker of fall risk, are unknown. The effects of RAS on stride time variability, swing time variability and spatial‐temporal measures were examined during 100‐m walks with the RAS beat set to 100 and 110% of each subject's usual cadence in 29 patients with idiopathic PD and 26 healthy age‐matched controls. Carryover effects were also evaluated. During usual walking, variability was significantly higher (worse) in the patients with PD compared with the controls (P < 0.01). For the patients with PD, RAS at 100% improved gait speed, stride length and swing time (P < 0.02) but did not significantly affect variability. With RAS at 110%, reductions in variability were also observed (P < 0.03) and these effects persisted 2 and 15 min later. In the control subjects, the positive effects of RAS were not observed. For example, RAS increased stride time variability at 100 and 110%. These results demonstrate that RAS enables more automatic movement and reduces stride‐to‐stride variability in patients with PD. Further, these improvements are not simply a by‐product of changes in speed or stride length. After walking with RAS, there also appears to be a carryover effect that supports the possibility of motor plasticity in the networks controlling rhythmicity in PD and the potential for using RAS as an intervention to improve mobility and reduce fall risk.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jeffrey M. Hausdorff</name><affiliations><json:string>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</json:string><json:string>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</json:string><json:string>Division on Aging, Harvard Medical School, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Justine Lowenthal</name><affiliations><json:string>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</json:string><json:string>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</json:string></affiliations></json:item><json:item><name>Talia Herman</name><affiliations><json:string>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</json:string></affiliations></json:item><json:item><name>Leor Gruendlinger</name><affiliations><json:string>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</json:string></affiliations></json:item><json:item><name>Chava Peretz</name><affiliations><json:string>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</json:string><json:string>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</json:string></affiliations></json:item><json:item><name>Nir Giladi</name><affiliations><json:string>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</json:string><json:string>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</json:string><json:string>Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>gait variability</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>plasticity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rhythmic auditory stimulation</value></json:item></subject><articleId><json:string>EJN5810</json:string></articleId><language><json:string>eng</json:string></language><abstract>Patients with Parkinson's disease (PD) walk with a shortened stride length and high stride‐to‐stride variability, a measure associated with fall risk. Rhythmic auditory stimulation (RAS) improves stride length but the effects on stride‐to‐stride variability, a marker of fall risk, are unknown. The effects of RAS on stride time variability, swing time variability and spatial‐temporal measures were examined during 100‐m walks with the RAS beat set to 100 and 110% of each subject's usual cadence in 29 patients with idiopathic PD and 26 healthy age‐matched controls. Carryover effects were also evaluated. During usual walking, variability was significantly higher (worse) in the patients with PD compared with the controls (P > 0.01). For the patients with PD, RAS at 100% improved gait speed, stride length and swing time (P > 0.02) but did not significantly affect variability. With RAS at 110%, reductions in variability were also observed (P > 0.03) and these effects persisted 2 and 15 min later. In the control subjects, the positive effects of RAS were not observed. For example, RAS increased stride time variability at 100 and 110%. These results demonstrate that RAS enables more automatic movement and reduces stride‐to‐stride variability in patients with PD. Further, these improvements are not simply a by‐product of changes in speed or stride length. After walking with RAS, there also appears to be a carryover effect that supports the possibility of motor plasticity in the networks controlling rhythmicity in PD and the potential for using RAS as an intervention to improve mobility and reduce fall risk.</abstract><qualityIndicators><score>7.964</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1624</abstractCharCount><pdfWordCount>6174</pdfWordCount><pdfCharCount>37373</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>247</abstractWordCount></qualityIndicators><title>Rhythmic auditory stimulation modulates gait variability in Parkinson's 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disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Rhythmic auditory stimulation modulates gait variability in Parkinson's disease</title><author><persName><forename type="first">Jeffrey M.</forename><surname>Hausdorff</surname></persName><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation><affiliation>Division on Aging, Harvard Medical School, Boston, MA, USA</affiliation></author><author><persName><forename type="first">Justine</forename><surname>Lowenthal</surname></persName><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation></author><author><persName><forename type="first">Talia</forename><surname>Herman</surname></persName><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation></author><author><persName><forename type="first">Leor</forename><surname>Gruendlinger</surname></persName><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation></author><author><persName><forename type="first">Chava</forename><surname>Peretz</surname></persName><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation></author><author><persName><forename type="first">Nir</forename><surname>Giladi</surname></persName><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation><affiliation>Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation></author></analytic><monogr><title level="j">European Journal of Neuroscience</title><idno type="pISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><idno type="DOI">10.1111/(ISSN)1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-10"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="2369">2369</biblScope><biblScope unit="page" to="2375">2375</biblScope></imprint></monogr><idno type="istex">D101ECC4713784EC04554F09B1237CA4DC874DF4</idno><idno type="DOI">10.1111/j.1460-9568.2007.05810.x</idno><idno type="ArticleID">EJN5810</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Patients with Parkinson's disease (PD) walk with a shortened stride length and high stride‐to‐stride variability, a measure associated with fall risk. Rhythmic auditory stimulation (RAS) improves stride length but the effects on stride‐to‐stride variability, a marker of fall risk, are unknown. The effects of RAS on stride time variability, swing time variability and spatial‐temporal measures were examined during 100‐m walks with the RAS beat set to 100 and 110% of each subject's usual cadence in 29 patients with idiopathic PD and 26 healthy age‐matched controls. Carryover effects were also evaluated. During usual walking, variability was significantly higher (worse) in the patients with PD compared with the controls (P < 0.01). For the patients with PD, RAS at 100% improved gait speed, stride length and swing time (P < 0.02) but did not significantly affect variability. With RAS at 110%, reductions in variability were also observed (P < 0.03) and these effects persisted 2 and 15 min later. In the control subjects, the positive effects of RAS were not observed. For example, RAS increased stride time variability at 100 and 110%. These results demonstrate that RAS enables more automatic movement and reduces stride‐to‐stride variability in patients with PD. Further, these improvements are not simply a by‐product of changes in speed or stride length. After walking with RAS, there also appears to be a carryover effect that supports the possibility of motor plasticity in the networks controlling rhythmicity in PD and the potential for using RAS as an intervention to improve mobility and reduce fall risk.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>gait variability</term></item><item><term>Parkinson's disease</term></item><item><term>plasticity</term></item><item><term>rhythmic auditory stimulation</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D101ECC4713784EC04554F09B1237CA4DC874DF4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1460-9568</doi><issn type="print">0953-816X</issn><issn type="electronic">1460-9568</issn><idGroup><id type="product" value="EJN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROSCIENCE">European Journal of Neuroscience</title></titleGroup></publicationMeta><publicationMeta level="part" position="10008"><doi origin="wiley">10.1111/ejn.2007.26.issue-8</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue" number="8">8</numbering></numberingGroup><coverDate startDate="2007-10">October 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="26" status="forIssue"><doi origin="wiley">10.1111/j.1460-9568.2007.05810.x</doi><idGroup><id type="unit" value="EJN5810"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Research Reports</title></titleGroup><eventGroup><event type="firstOnline" date="2007-10-17"></event><event type="publishedOnlineFinalForm" date="2007-10-17"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.16 mode:FullText" date="2010-08-27"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="2369">2369</numbering><numbering type="pageLast" number="2375">2375</numbering></numberingGroup><correspondenceTo>Dr Jeffrey M. Hausdorff, as above.
E‐mail: <email>jhausdor@bidmc.harvard.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EJN.EJN5810.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 16 May 2007, revised 24 July 2007, accepted 4 August 2007</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="53"></count><count type="wordTotal" number="4903"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Rhythmic auditory stimulation modulates gait variability in Parkinson's disease</title><title type="shortAuthors">J. M. Hausdorff <i>et al.</i></title><title type="short">Effects of RAS on gait variability in PD</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2 #a3"><personName><givenNames>Jeffrey M.</givenNames><familyName>Hausdorff</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1 #a2"><personName><givenNames>Justine</givenNames><familyName>Lowenthal</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Talia</givenNames><familyName>Herman</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Leor</givenNames><familyName>Gruendlinger</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1 #a2"><personName><givenNames>Chava</givenNames><familyName>Peretz</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1 #a2 #a4"><personName><givenNames>Nir</givenNames><familyName>Giladi</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="IL"><unparsedAffiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="IL"><unparsedAffiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation>Division on Aging, Harvard Medical School, Boston, MA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="IL"><unparsedAffiliation>Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">gait variability</keyword><keyword xml:id="k2">Parkinson's disease</keyword><keyword xml:id="k3">plasticity</keyword><keyword xml:id="k4">rhythmic auditory stimulation </keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Patients with Parkinson's disease (PD) walk with a shortened stride length and high stride‐to‐stride variability, a measure associated with fall risk. Rhythmic auditory stimulation (RAS) improves stride length but the effects on stride‐to‐stride variability, a marker of fall risk, are unknown. The effects of RAS on stride time variability, swing time variability and spatial‐temporal measures were examined during 100‐m walks with the RAS beat set to 100 and 110% of each subject's usual cadence in 29 patients with idiopathic PD and 26 healthy age‐matched controls. Carryover effects were also evaluated. During usual walking, variability was significantly higher (worse) in the patients with PD compared with the controls (<i>P</i> < 0.01). For the patients with PD, RAS at 100% improved gait speed, stride length and swing time (<i>P</i> < 0.02) but did not significantly affect variability. With RAS at 110%, reductions in variability were also observed (<i>P</i> < 0.03) and these effects persisted 2 and 15 min later. In the control subjects, the positive effects of RAS were not observed. For example, RAS increased stride time variability at 100 and 110%. These results demonstrate that RAS enables more automatic movement and reduces stride‐to‐stride variability in patients with PD. Further, these improvements are not simply a by‐product of changes in speed or stride length. After walking with RAS, there also appears to be a carryover effect that supports the possibility of motor plasticity in the networks controlling rhythmicity in PD and the potential for using RAS as an intervention to improve mobility and reduce fall risk.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Rhythmic auditory stimulation modulates gait variability in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated"><title>Effects of RAS on gait variability in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Rhythmic auditory stimulation modulates gait variability in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Jeffrey M.</namePart><namePart type="family">Hausdorff</namePart><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation><affiliation>Division on Aging, Harvard Medical School, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Justine</namePart><namePart type="family">Lowenthal</namePart><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Talia</namePart><namePart type="family">Herman</namePart><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leor</namePart><namePart type="family">Gruendlinger</namePart><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chava</namePart><namePart type="family">Peretz</namePart><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nir</namePart><namePart type="family">Giladi</namePart><affiliation>Laboratory for Gait and Neurodynamics, Movement Disorders Unit and Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel</affiliation><affiliation>Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation><affiliation>Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2007-10</dateIssued><edition>Received 16 May 2007, revised 24 July 2007, accepted 4 August 2007</edition><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">53</extent><extent unit="words">4903</extent></physicalDescription><abstract lang="en">Patients with Parkinson's disease (PD) walk with a shortened stride length and high stride‐to‐stride variability, a measure associated with fall risk. Rhythmic auditory stimulation (RAS) improves stride length but the effects on stride‐to‐stride variability, a marker of fall risk, are unknown. The effects of RAS on stride time variability, swing time variability and spatial‐temporal measures were examined during 100‐m walks with the RAS beat set to 100 and 110% of each subject's usual cadence in 29 patients with idiopathic PD and 26 healthy age‐matched controls. Carryover effects were also evaluated. During usual walking, variability was significantly higher (worse) in the patients with PD compared with the controls (P < 0.01). For the patients with PD, RAS at 100% improved gait speed, stride length and swing time (P < 0.02) but did not significantly affect variability. With RAS at 110%, reductions in variability were also observed (P < 0.03) and these effects persisted 2 and 15 min later. In the control subjects, the positive effects of RAS were not observed. For example, RAS increased stride time variability at 100 and 110%. These results demonstrate that RAS enables more automatic movement and reduces stride‐to‐stride variability in patients with PD. Further, these improvements are not simply a by‐product of changes in speed or stride length. After walking with RAS, there also appears to be a carryover effect that supports the possibility of motor plasticity in the networks controlling rhythmicity in PD and the potential for using RAS as an intervention to improve mobility and reduce fall risk.</abstract><subject lang="en"><genre>Keywords</genre><topic>gait variability</topic><topic>Parkinson's disease</topic><topic>plasticity</topic><topic>rhythmic auditory stimulation</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neuroscience</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0953-816X</identifier><identifier type="eISSN">1460-9568</identifier><identifier type="DOI">10.1111/(ISSN)1460-9568</identifier><identifier type="PublisherID">EJN</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>2369</start><end>2375</end><total>7</total></extent></part></relatedItem><identifier type="istex">D101ECC4713784EC04554F09B1237CA4DC874DF4</identifier><identifier type="DOI">10.1111/j.1460-9568.2007.05810.x</identifier><identifier type="ArticleID">EJN5810</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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